Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | AGXT | P21549 | 2/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 2/20 | 0.41 |
| ▸ | MC5R | P33032 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthalene SCHEMBL693196 | 1.00 | CYP2A6 (0.57) | CYP2A6ALOX12KDM4EAGXTHTR1B | |
| Naphthalene SCHEMBL28139070 | 0.96 | CYP2A6 (0.61) | CYP2A6ALOX12KDM4EAGXTHTR1B | |
| Naphthalene SCHEMBL28427291 | 0.84 | MAOA (0.50) | CYP2A6ALOX12AGXTHTR1BHTR2A | |
| Naphthalene SCHEMBL28014623 | 0.83 | CYP2A6 (0.53) | CYP2A6ALOX12KDM4EAGXTTAAR1 | |
| Naphthalene SCHEMBL29450562 | 0.80 | CYP2A6 (0.89) | CYP2A6ALOX12AGXTALDH1A1HSD17B10 | |
| Naphthalene SCHEMBL594460 | 0.80 | CYP2A6 (0.89) | CYP2A6ALOX12AGXTALDH1A1HSD17B10 | |
| Naphthalene SCHEMBL5950127 | 0.80 | CYP2A6 (0.89) | CYP2A6ALOX12AGXTALDH1A1HSD17B10 | |
| Naphthalene SCHEMBL9318031 | 0.80 | CYP2A6 (0.89) | CYP2A6ALOX12AGXTALDH1A1HSD17B10 | |
| Naphthalene SCHEMBL28744334 | 0.80 | CYP2A6 (0.89) | CYP2A6ALOX12AGXTALDH1A1HSD17B10 | |
| Naphthalene SCHEMBL8525098 | 0.80 | CYP2A6 (0.89) | CYP2A6ALOX12AGXTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 261 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117805042-A | Photoelectric detection method and analyzer for in-situ analysis of hertz-level seawater nutrient salt | 中国科学院海洋研究所 | 2024-04-02 | — | — | CN | claimed |
| CN-117491300-A | Method for reducing interference of nitrite detection factors in infant milk powder | 山东诺瓦生物技术有限公司 | 2024-02-02 | — | — | CN | claimed |
| CN-117368189-A | Method for rapidly detecting nitrite in food by adopting powder reagent | 云南孚尔质量检验检测有限公司 | 2024-01-09 | — | — | CN | claimed |
| CN-117051073-A | Method for detecting microbial contamination of pickled vegetables | 重庆师范大学 | 2023-11-14 | — | — | CN | claimed |
| CN-116893150-A | Gas phase molecular absorption spectrum-naphthalene ethylenediamine hydrochloride spectrophotometry method and device for fixing total nitrogen in pollution source waste gas | 中国环境监测总站 | 2023-10-17 | — | — | CN | claimed |
| CN-116879284-A | Kit for detecting nitrate in water, detection system and related method thereof | 深圳先进技术研究院 | 2023-10-13 | — | — | CN | claimed |
| CN-116879285-A | Kit for detecting trace nitrite, detection system and related method thereof | 深圳先进技术研究院 | 2023-10-13 | — | — | CN | claimed |
| CN-116831273-A | Application of mimicking staphylococcus HZ01 to substitution of partial nitrite in meat products | 浙江省农业科学院 | 2023-10-03 | — | — | CN | claimed |
| CN-116754503-A | Method for detecting total nitrogen concentration in aquaculture water and application thereof | 厦门斯坦道科学仪器股份有限公司 | 2023-09-15 | — | — | CN | claimed |
| CN-114891701-B | Staphylococcus HZ 01-mimicking bacterium agent and application thereof | 浙江省农业科学院 | 2023-07-25 | — | — | CN | claimed |
| CN-114137102-B | Method for measuring clenbuterol hydrochloride content in ambroxol oral solution | 北京鑫开元医药科技有限公司 | 2023-06-16 | — | — | CN | claimed |
| CN-116263409-A | Method for detecting imidacloprid pesticide based on nano enzyme | 中国科学院大连化学物理研究所 | 2023-06-16 | — | — | CN | claimed |
| CN-106769929-B | Atmospheric gaseous nitric acid online measurement method and device based on flow injection analysis | 北京大学 | 2023-06-09 | — | — | CN | claimed |
| CN-115343241-B | On-site rapid sampling detection device and detection method for water for livestock breeding | 山东畜牧兽医职业学院 | 2023-06-06 | — | — | CN | claimed |
| CN-115575390-B | Combined reagent for monitoring water quality and application method thereof | 广东省环境科学研究院 | 2023-05-30 | — | — | CN | claimed |
| CN-105954214-B | A kind of vanadium trichloride mixing powder and its application in terms of Fast Determination of Nitrate Content in Food content | 华南农业大学 | 2019-06-21 | — | — | CN | claimed |
| CN-108410761-A | One plant has drop nitrite, oxidation resistant Lactobacillus rhamnosus and method for screening and separating | 山东凤凰生物有限公司 | 2018-08-17 | — | — | CN | claimed |
| CN-108004177-A | A kind of lactobacillus paracasei and its characteristic research of degradable nitrite | 江南大学 | 2018-05-08 | — | — | CN | claimed |
| CN-105969680-A | Lactobacillus pentosus for reducing cholesterol and nitrite and screening method thereof | 贵州大学 | 2016-09-28 | — | — | CN | claimed |
| CN-105695363-A | Lactobacillus paraplantarum capable of reducing cholesterol and nitrite and screening method thereof | 贵州大学 | 2016-06-22 | — | — | CN | claimed |