Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | AGXT | P21549 | 2/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 2/20 | 0.41 |
| ▸ | MC5R | P33032 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthalene SCHEMBL23610623 | 1.00 | CYP2A6 (0.57) | CYP2A6ALOX12KDM4EAGXTHTR1B | |
| Naphthalene SCHEMBL28139070 | 0.96 | CYP2A6 (0.61) | CYP2A6ALOX12KDM4EAGXTHTR1B | |
| Naphthalene SCHEMBL28427291 | 0.84 | MAOA (0.50) | CYP2A6ALOX12AGXTHTR1BHTR2A | |
| Naphthalene SCHEMBL28014623 | 0.83 | CYP2A6 (0.53) | CYP2A6ALOX12KDM4EAGXTTAAR1 | |
| Naphthalene SCHEMBL29450562 | 0.80 | CYP2A6 (0.89) | CYP2A6ALOX12AGXTALDH1A1HSD17B10 | |
| Naphthalene SCHEMBL594460 | 0.80 | CYP2A6 (0.89) | CYP2A6ALOX12AGXTALDH1A1HSD17B10 | |
| Naphthalene SCHEMBL5950127 | 0.80 | CYP2A6 (0.89) | CYP2A6ALOX12AGXTALDH1A1HSD17B10 | |
| Naphthalene SCHEMBL9318031 | 0.80 | CYP2A6 (0.89) | CYP2A6ALOX12AGXTALDH1A1HSD17B10 | |
| Naphthalene SCHEMBL28744334 | 0.80 | CYP2A6 (0.89) | CYP2A6ALOX12AGXTALDH1A1HSD17B10 | |
| Naphthalene SCHEMBL8525098 | 0.80 | CYP2A6 (0.89) | CYP2A6ALOX12AGXTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113218895-B | Detection system and method for determining total nitrogen content in water | 苏州微湃医疗科技有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-113218895-A | Detection system and method for determining total nitrogen content in water | 苏州微湃医疗科技有限公司 | 2021-08-06 | — | — | CN | claimed |
| CN-115702909-B | Sargassum fusiforme fermentation mixture and preparation method and application thereof | 青岛康迈臣生物科技有限责任公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-117402082-A | Alpha-cyano diaryl ethylene fluorescent material capable of optically releasing nitric oxide, preparation and application | 西安交通大学 | 2024-01-16 | — | — | CN | disclosed |
| CN-117304162-A | Novel cicada slough acetyldopamine trimer with anti-inflammatory activity and preparation method and application thereof | 江苏省中医药研究院 | 2023-12-29 | — | — | CN | disclosed |
| CN-116785433-B | Photo-thermal-photodynamic driven NO release synergistic cationic sterilization material and application thereof | 潍坊医学院 | 2023-10-20 | — | — | CN | disclosed |
| CN-116785433-A | Photo-thermal-photodynamic driven NO release synergistic cationic sterilization material and application thereof | 潍坊医学院 | 2023-09-22 | — | — | CN | disclosed |
| CN-114908128-B | Solid fermentation method, metazoan and animal feed | 广东大泽农生物科技股份有限公司 | 2023-04-28 | — | — | CN | disclosed |
| CN-113218895-B | Detection system and method for determining total nitrogen content in water | 苏州微湃医疗科技有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-109827916-B | Water quality nitrate detection method based on zinc-cadmium reduction salt-free effect | 国家海洋局东海环境监测中心(国家海洋局东海海洋工程勘察设计研究所) | 2021-11-16 | — | — | CN | disclosed |
| CN-113218895-A | Detection system and method for determining total nitrogen content in water | 苏州微湃医疗科技有限公司 | 2021-08-06 | — | — | CN | disclosed |
| US-20100252450-A1 | ELECTRODE AND SENSOR HAVING CARBON NANOSTRUCTURES | RIEHL-JOHNSON HOLDINGS, LLC | 2010-10-07 | — | — | US | disclosed |
| US-20080145465-A1 | Sesquiterpene lactone extract from artemisia leucodes for reducing inflammation and down-regulating pro-inflammatory gene expression | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2008-06-19 | — | — | US | disclosed |
| WO-2008054756-A2 | SESQUITERPENE LACTONES FROM ARTEMISIA LEUCODES AS ANTI-INFLAMMATORY AND GENE REGULATORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2008-05-08 | — | — | WO | disclosed |
| US-7226623-B2 | In vitro and in vivo anti-inflammatory effects of a sesquiterpene lactone extract from chicory (Cichorium intybus L.) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2007-06-05 | — | — | US | disclosed |
| US-20070098827-A1 | IN VITRO AND IN VIVO ANTI-INFLAMMATORY EFFECTS OF A SESQUITERPENE LACTONE EXTRACT FROM CHICORY (CICHORIUM INTYBUS L.) | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2007-05-03 | — | — | US | disclosed |
| US-6605447-B2 | Detecting adjustment in nitric oxide synthase expression in cells; obtain samle, incubate with substrate, monitor gene xpression, compare to control, evaluate nitric oxide synthase | YALE UNIVERSITY | 2003-08-12 | — | — | US | disclosed |
| US-20020164658-A1 | METHODS AND MEANS OF DETECTING NITRIC OXIDE SYNTHASE | NATIONAL INSTITUTES OF HEALTH, THE | 2002-11-07 | — | — | US | disclosed |
| EP-0907747-A1 | METHODS AND MEANS OF DETECTING NITRIC OXIDE SYNTHASE | YALE UNIVERSITY (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997034014-A1 | METHODS AND MEANS OF DETECTING NITRIC OXIDE SYNTHASE | YALE UNIVERSITY (US) | 1997-09-18 | — | — | WO | disclosed |