Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.37 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29929645 | 1.00 | MAPT (0.42) | MAPTKMT2AALDH1A1L3MBTL1HTT | |
| SCHEMBL23611886 | 0.92 | MAPT (0.43) | MAPTKMT2AALDH1A1L3MBTL1HTT | |
| SCHEMBL30053407 | 0.92 | MAPT (0.43) | MAPTKMT2AALDH1A1L3MBTL1HTT | |
| SCHEMBL29929291 | 0.89 | MAPT (0.41) | MAPTKMT2AALDH1A1L3MBTL1HTT | |
| SCHEMBL26977540 | 0.89 | MAPT (0.41) | MAPTKMT2AALDH1A1L3MBTL1HTT | |
| SCHEMBL29929049 | 0.86 | VCAM1 (0.41) | MAPTKMT2AALDH1A1L3MBTL1HTT | |
| SCHEMBL26977398 | 0.86 | VCAM1 (0.41) | MAPTKMT2AALDH1A1L3MBTL1HTT | |
| SCHEMBL26980327 | 0.81 | CDC7 (0.44) | MAPTKMT2AALDH1A1L3MBTL1HTT | |
| SCHEMBL30671846 | 0.81 | CDC7 (0.44) | MAPTKMT2AALDH1A1L3MBTL1HTT | |
| SCHEMBL26977136 | 0.77 | CCND3 (0.49) | MAPTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240190849-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | TYRA BIOSCIENCES, INC. | 2024-06-13 | — | — | US | disclosed |
| EP-4297873-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | Tyra Biosciences, Inc. (US) | 2024-01-03 | — | — | EP | disclosed |
| CN-117136184-A | Aminopyrimidine compounds and methods of use thereof | 泰拉生物科学公司 | 2023-11-28 | — | — | CN | disclosed |
| US-20230115945-A1 | AMINOPYRIMIDINE COMPOUNDS | TYRA BIOSCIENCES, INC. | 2023-04-13 | — | — | US | disclosed |
| EP-4085055-A1 | AMINOPYRIMIDINE COMPOUNDS | Tyra Biosciences, Inc. (US) | 2022-11-09 | — | — | EP | disclosed |
| WO-2022182972-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | TYRA BIOSCIENCES, INC. (US) | 2022-09-01 | — | — | WO | disclosed |
| WO-2021138392-A1 | AMINOPYRIMIDINE COMPOUNDS | TYRA BIOSCIENCES, INC. (US) | 2021-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230115945-A1 | AMINOPYRIMIDINE COMPOUNDS | FGFR2, FGFR1, FGFR4 | MAPT 3238/4885KMT2A 1643/4885ALDH1A1 428/4885 |
| US-20240190849-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | DPYD, TYMP, TYMS | MAPT 3848/4885KMT2A 1776/4885ALDH1A1 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.