Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2324340 | 0.94 | SMN1; SMN2 (0.47) | HDAC1TOP1SMN1; SMN2AVPR1BALDH1A1 | |
| SCHEMBL2329922 | 0.91 | PDE3B (0.46) | HDAC1TOP1PDE3BPDE3AP2RY12 | |
| SCHEMBL2330628 | 0.87 | HDAC1 (0.44) | HDAC1TOP1SMN1; SMN2AVPR1BALDH1A1 | |
| SCHEMBL4589067 | 0.85 | ALDH1A1 (0.44) | HDAC1TOP1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL7529908 | 0.85 | SMN1; SMN2 (0.45) | HDAC1TOP1SMN1; SMN2AVPR1BALDH1A1 | |
| SCHEMBL2360007 | 0.85 | SIRT2 (0.41) | HDAC1TOP1AVPR1BSIRT2SIRT1 | |
| SCHEMBL2324500 | 0.84 | HDAC1 (0.46) | HDAC1TOP1PDE3BPDE3AAVPR1B | |
| SCHEMBL2324248 | 0.84 | PDE3B (0.42) | HDAC1TOP1PDE3BPDE3AP2RY12 | |
| SCHEMBL2326876 | 0.83 | HDAC1 (0.59) | HDAC1TOP1HDAC8HDAC6HDAC3 | |
| SCHEMBL2324135 | 0.83 | HDAC1 (0.48) | HDAC1TOP1PDE3BPDE3AAVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246808-B1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | BAYER SCHERING PHARMA AG (DE) | 2011-08-17 | — | — | EP | disclosed |