Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2324340 | 0.91 | SMN1; SMN2 (0.47) | SMN1; SMN2HDAC1TOP1AVPR1BEGFR | |
| SCHEMBL2330628 | 0.90 | HDAC1 (0.44) | SMN1; SMN2HDAC1TOP1AVPR1BEGFR | |
| SCHEMBL2361332 | 0.85 | HDAC1 (0.43) | SMN1; SMN2HDAC1TOP1AVPR1BEGFR | |
| SCHEMBL4589067 | 0.82 | ALDH1A1 (0.44) | SMN1; SMN2HDAC1TOP1EGFRMAPT | |
| SCHEMBL2324500 | 0.80 | HDAC1 (0.46) | HDAC1TOP1AVPR1BEGFRHDAC3 | |
| SCHEMBL2331959 | 0.80 | HDAC1 (0.43) | HDAC1TOP1AVPR1BEGFRHDAC3 | |
| SCHEMBL6481753 | 0.80 | VDR (0.47) | SMN1; SMN2HDAC1TOP1AVPR1BHDAC8 | |
| SCHEMBL2326876 | 0.80 | HDAC1 (0.59) | HDAC1TOP1HDAC3HDAC4HDAC7 | |
| SCHEMBL2324135 | 0.79 | HDAC1 (0.48) | HDAC1TOP1AVPR1BHDAC3HDAC4 | |
| SCHEMBL2327764 | 0.79 | HPGD (0.53) | SMN1; SMN2HDAC1TOP1AVPR1BEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020006948-A1 | 1,2 diarylbenzimdazoles and their pharmaceutical use | SCHERING AG | 2002-01-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020006948-A1 | 1,2 diarylbenzimdazoles and their pharmaceutical use | CYP2E1, CYP1B1, CYP1A1 | SMN1; SMN2 933/4885HDAC1 331/4885TOP1 2199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.