Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14638034 | 0.84 | KMT2A (0.49) | LMNAKMT2AGAARAB9AMEN1 | |
| SCHEMBL2361385 | 0.81 | LMNA (0.67) | LMNAKMT2AMEN1ATMPTGER1 | |
| SCHEMBL13363517 | 0.78 | LMNA (0.65) | LMNAKMT2AGAARAB9AMEN1 | |
| SCHEMBL13362271 | 0.77 | LMNA (0.61) | LMNAKMT2AGAARAB9AMEN1 | |
| SCHEMBL2360064 | 0.77 | LMNA (0.48) | LMNAKMT2ARAB9AMEN1ATM | |
| SCHEMBL4683986 | 0.75 | PTGER1 (0.66) | PTGER1 | |
| SCHEMBL17627074 | 0.75 | LMNA (0.37) | LMNAGAARAB9APTGER1HTT | |
| SCHEMBL4684637 | 0.74 | PTGER1 (0.59) | PTGER1 | |
| SCHEMBL4683882 | 0.72 | PTGER1 (0.61) | PTGER1 | |
| SCHEMBL4681478 | 0.72 | PTGER1 (0.77) | PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356113-B1 | HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS | BAYER IP GMBH (DE) | 2015-01-07 | — | — | EP | disclosed |
| EP-2356114-A1 | AMINOALKYL-SUBSTITUTED COMPOUNDS AS HIF INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010054762-A1 | AMINOALKYL-SUBSTITUTED COMPOUNDS AS HIF INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-05-20 | — | — | WO | disclosed |