SCHEMBL2360064

SCHEMBL2360064

Cc1cc(OC(=O)O)cn1Cc1ccc(Cl)nc1

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
KMT2A Q03164 4/20 0.44
MEN1 O00255 1/20 0.44
ATM Q13315 1/20 0.44
ALDH1A1 P00352 2/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
CHRNA1 P02708 1/20 0.40
CHRNB2 P17787 1/20 0.40
CHRNA7 P36544 1/20 0.40
CHRNA4 P43681 1/20 0.40
TERT O14746 1/20 0.40
PPARG P37231 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2360062 0.82 LMNA (0.50) LMNAL3MBTL1KMT2AMEN1ATM
SCHEMBL13362335 0.79 KMT2A (0.52) LMNAL3MBTL1KMT2AMEN1ATM
SCHEMBL2361387 0.77 LMNA (0.62) LMNAL3MBTL1KMT2AMEN1ATM
SCHEMBL25565198 0.74 ALDH1A1 (0.41) LMNAL3MBTL1KMT2AMEN1ATM
SCHEMBL9154821 0.70 NAPRT (0.52) LMNAL3MBTL1ALDH1A1NPC1RAB9A
SCHEMBL4684120 0.69 PTGER1 (0.63)
SCHEMBL2361385 0.69 LMNA (0.67) LMNAKMT2AMEN1ATM
SCHEMBL3350356 0.68 KMT2A (0.50) LMNAL3MBTL1KMT2AMEN1ATM
SCHEMBL13363517 0.66 LMNA (0.65) LMNAL3MBTL1KMT2AMEN1ATM
SCHEMBL7508721 0.65 LMNA (0.55) LMNAL3MBTL1KMT2AMEN1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2356113-B1 HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS BAYER IP GMBH (DE) 2015-01-07 EP disclosed
EP-2356112-A1 HETEROAROMATIC COMPOUNDS FOR USE AS HIF INHIBITORS Bayer Schering Pharma Aktiengesellschaft (DE) 2011-08-17 EP disclosed
EP-2356113-A1 HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS Bayer Schering Pharma Aktiengesellschaft (DE) 2011-08-17 EP disclosed
WO-2010054763-A1 HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-05-20 WO disclosed
WO-2010054764-A1 HETEROAROMATIC COMPOUNDS FOR USE AS HIF INHIBITORS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-05-20 WO disclosed