Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23615790 | 0.86 | MAPT (0.59) | MAPTMEN1KMT2ATP53TDP1 | |
| SCHEMBL650217 | 0.78 | MAPT (0.86) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL22761325 | 0.71 | TP53 (0.55) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL22761105 | 0.71 | ALOX5 (0.51) | MAPTMEN1KMT2ATDP1GAA | |
| SCHEMBL20582267 | 0.71 | ALOX5 (0.51) | MAPTMEN1KMT2ATDP1GAA | |
| SCHEMBL23615744 | 0.70 | TP53 (0.49) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL23615677 | 0.70 | ALDH1A1 (0.50) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL22761324 | 0.70 | ALDH1A1 (0.50) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL22761257 | 0.70 | TP53 (0.49) | MAPTLMNAMEN1KMT2ATP53 | |
| SCHEMBL29385380 | 0.69 | ALDH1A1 (0.63) | MAPTLMNAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634957-B1 | NMDA RECEPTOR MODULATORS, COMPOSITIONS COMPRISING SAME AND USE OF THESE COMPOUNDS IN THE TREATMENT OF DISEASES INVOLVING THE CENTRAL NERVOUS SYSTEM | ADPUERIVITAM (FR) | 2021-07-07 | — | — | EP | disclosed |