Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23617253 | 0.89 | TBXAS1 (0.47) | TBXAS1PKMCYP4F2CYP4A11TSHR | |
| SCHEMBL23425588 | 0.86 | TBXAS1 (0.47) | TBXAS1PKMCYP4F2CYP4A11TSHR | |
| SCHEMBL23241478 | 0.86 | TBXAS1 (0.47) | TBXAS1PKMCYP4F2CYP4A11TSHR | |
| SCHEMBL7888801 | 0.85 | TBXAS1 (0.49) | TBXAS1PKMCYP4F2CYP4A11TSHR | |
| SCHEMBL21455171 | 0.84 | CXCL8 (0.48) | TSHRL3MBTL1 | |
| SCHEMBL23229153 | 0.84 | TBXAS1 (0.48) | TBXAS1PKMCYP4F2CYP4A11SMN1; SMN2 | |
| SCHEMBL23241666 | 0.83 | TBXAS1 (0.42) | TBXAS1PKMCYP4F2CYP4A11TSHR | |
| SCHEMBL23229004 | 0.83 | TBXAS1 (0.47) | TBXAS1PKMCYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL21455709 | 0.82 | TBXAS1 (0.46) | TBXAS1PKMCYP4F2CYP4A11TSHR | |
| SCHEMBL23241624 | 0.82 | MAPT (0.38) | PKMTSHRALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939658-A1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |
| EP-3687506-B1 | SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS | BIOCRYST PHARM INC (US) | 2021-07-07 | — | — | EP | disclosed |