Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 12/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 12/20 | 0.50 |
| ▸ | TSHR | P16473 | 11/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | APLNR | P35414 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22301803 | 0.85 | DHFR (0.47) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL873390 | 0.83 | DHFR (0.55) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL23852696 | 0.80 | APLNR (0.59) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL31309621 | 0.80 | PDE4B (0.44) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL30443473 | 0.80 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL25466388 | 0.80 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL17105218 | 0.78 | CYP1A2 (0.55) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL22307619 | 0.78 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL27875036 | 0.78 | APLNR (0.52) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL27376118 | 0.78 | KDM4C (0.53) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147092-A1 | COMBINATION THERAPY COMPRISING A2A/A2B INHIBITORS, PD-1/PD-L1 INHIBITORS, AND ANTI-CD73 ANTIBODIES | INCYTE CORPORATION (US) | 2022-07-07 | — | — | WO | disclosed |
| WO-2021138512-A1 | COMBINATION THERAPY COMPRISING A2A/A2B AND PD-1/PD-L1 INHIBITORS | INCYTE CORPORATION (US) | 2021-07-08 | — | — | WO | disclosed |