SCHEMBL23620329

SCHEMBL23620329

CCc1cc(OCOCC[Si](C)(C)C)c(F)cc1-c1ccc2c(-c3nc(C=O)c[nH]3)nn(COCC[Si](C)(C)C)c2c1

nearest known ligand 0.35

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 3/20 0.35
FEN1 P39748 3/20 0.35
F2RL1 P55085 1/20 0.31
DGAT1 O75907 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23620326 0.86 ALOX5AP (0.33) ALOX5APFEN1F2RL1DGAT1
SCHEMBL29913956 0.86 ALOX5AP (0.33) ALOX5APFEN1F2RL1DGAT1
SCHEMBL28630369 0.79 ALOX5AP (0.34) ALOX5APFEN1F2RL1DGAT1
SCHEMBL31303180 0.79 ALOX5AP (0.31) ALOX5APFEN1F2RL1DGAT1
SCHEMBL23620253 0.79 ALOX5AP (0.34) ALOX5APFEN1F2RL1DGAT1
SCHEMBL29198324 0.79 DGAT1 (0.33) ALOX5APFEN1F2RL1DGAT1
SCHEMBL29913954 0.79 ALOX5AP (0.34) ALOX5APFEN1F2RL1DGAT1
SCHEMBL29198325 0.78 ALOX5AP (0.32) ALOX5APFEN1DGAT1
SCHEMBL29198333 0.78 ALOX5AP (0.34) ALOX5APFEN1DGAT1
SCHEMBL29198334 0.77 ALOX5AP (0.32) ALOX5APFEN1DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021136345-A1 JAK INHIBITOR COMPOUND AND USE THEREOF 路良 2021-07-08 WO disclosed