SCHEMBL23622145

SCHEMBL23622145

c1ccc([Si](c2ccccc2)(c2ccc(-c3nc(-n4c5ccccc5c5ccccc54)cc(-n4c5ccccc5c5ccccc54)n3)cc2)c2ccc(-c3nc(-n4c5ccccc5c5ccccc54)nc(-n4c5ccccc5c5ccccc54)n3)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.38
ATM Q13315 2/20 0.34
KDM4E B2RXH2 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
NPSR1 Q6W5P4 4/20 0.33
MAPT P10636 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
HSD17B10 Q99714 1/20 0.33
HPGD P15428 1/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
USP2 O75604 1/20 0.31
LMNA P02545 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
ABCB1 P08183 1/20 0.30
ABCG2 Q9UNQ0 1/20 0.30
NPC1 O15118 1/20 0.30
XBP1 P17861 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24089272 0.94 HTT (0.41) HTTATMKDM4EL3MBTL1NPSR1
SCHEMBL23622632 0.94 HTT (0.41) HTTATMKDM4EL3MBTL1NPSR1
SCHEMBL23622148 0.92 KDM4E (0.33) HTTATMKDM4EL3MBTL1
SCHEMBL23622551 0.92 ATM (0.40) HTTATMKDM4EL3MBTL1NPSR1
SCHEMBL23622354 0.92 ATM (0.40) HTTATMKDM4EL3MBTL1NPSR1
SCHEMBL25874906 0.91 MAPK1 (0.40) HTTATMKDM4EL3MBTL1NPSR1
SCHEMBL23622149 0.90 MAPT (0.38) ATMKDM4EL3MBTL1NPSR1MAPT
SCHEMBL23622150 0.90 HTT (0.36) HTTATMKDM4EL3MBTL1NPSR1
SCHEMBL23622651 0.89 HTT (0.38) HTTATMKDM4EL3MBTL1NPSR1
SCHEMBL25874974 0.89 KDM4E (0.45) HTTATMKDM4EL3MBTL1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230363254-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-11-09 US disclosed
US-11716899-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-08-01 US disclosed
US-20210210700-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2021-07-08 US disclosed