Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.40 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SELL | P14151 | 1/20 | 0.39 |
| ▸ | SELP | P16109 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518292 | 0.88 | TP53 (0.46) | GRM1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL317576 | 0.84 | ALDH1A1 (0.57) | GRM1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL30149140 | 0.84 | ALDH1A1 (0.57) | GRM1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL30396337 | 0.82 | KDM4E (0.55) | GRM1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9183153 | 0.82 | KDM4E (0.55) | GRM1HPGDALDH1A1KDM4EHSD17B10 | |
| Bicarbonate SCHEMBL4612195 | 0.82 | KDM4E (0.55) | GRM1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6155380 | 0.77 | GRM1 (0.51) | GRM1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL25756313 | 0.75 | TP53 (0.49) | GRM1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL31315038 | 0.73 | HMGB1 (0.52) | GRM1HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1568514 | 0.73 | KDM4E (0.45) | GRM1HPGDKDM4EHSD17B10HMGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348859-A1 | PRODRUGS OF OXAZOLIDINONE CETP INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010039474-A1 | PRODRUGS OF OXAZOLIDINONE CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-04-08 | — | — | WO | disclosed |