SCHEMBL23622947

SCHEMBL23622947

O=C(O)c1c[nH]c2cc(F)c(Cl)cc12

nearest known ligand 0.56

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
F7 P08709 1/20 0.56
F3 P13726 1/20 0.56
PRKAB2 O43741 17/20 0.55
PRKAG1 P54619 17/20 0.55
PRKAA2 P54646 17/20 0.55
PRKAA1 Q13131 17/20 0.55
PRKAG3 Q9UGI9 17/20 0.55
PRKAG2 Q9UGJ0 17/20 0.55
PRKAB1 Q9Y478 17/20 0.55
GPR84 Q9NQS5 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3104933 0.93 PRKAB2 (0.59) F7F3PRKAB2PRKAG1PRKAA2
SCHEMBL30416918 0.85 PRKAB2 (0.59) F7F3PRKAB2PRKAG1PRKAA2
SCHEMBL17429453 0.85 PRKAB2 (0.59) F7F3PRKAB2PRKAG1PRKAA2
SCHEMBL23612266 0.85 PRKAG1 (0.66) F7F3PRKAB2PRKAG1PRKAA2
SCHEMBL10478126 0.84 KDM4E (0.60) F7F3PRKAB2PRKAG1PRKAA2
SCHEMBL17417668 0.79 PRKAB2 (0.58) F7F3PRKAB2PRKAG1PRKAA2
SCHEMBL31375035 0.79 PRKAB2 (0.55) F7F3PRKAB2PRKAG1PRKAA2
SCHEMBL23167845 0.79 PRKAB2 (0.54) F7F3PRKAB2PRKAG1PRKAA2
SCHEMBL6897941 0.79 PRKAB2 (0.55) F7F3PRKAB2PRKAG1PRKAA2
SCHEMBL17417592 0.77 CYP2C19 (0.52) F7F3PRKAB2PRKAG1PRKAA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118515600-A Isoindoline compound and medical application thereof 中国科学院上海药物研究所 2024-08-20 CN disclosed
US-20230127839-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2023-04-27 US disclosed
US-20230127839-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2023-04-27 US disclosed
WO-2021138434-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC. (US) 2021-07-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230127839-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 F7 4066/4885F3 4163/4885PRKAB2 158/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.