SCHEMBL23622948

SCHEMBL23622948

O=C(O)c1c[nH]c2c(Br)cc(Cl)cc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ F7 P08709 1/20 0.51
▸ F3 P13726 1/20 0.51
▸ CSNK2A2 P19784 4/20 0.44
▸ CSNK2B P67870 4/20 0.44
▸ CSNK2A1 P68400 4/20 0.44
▸ DYRK1A Q13627 1/20 0.43
▸ MCL1 Q07820 1/20 0.41
▸ PRKAB2 O43741 4/20 0.38
▸ PRKAG1 P54619 4/20 0.38
▸ PRKAA2 P54646 4/20 0.38
▸ PRKAA1 Q13131 4/20 0.38
▸ PRKAG3 Q9UGI9 4/20 0.38
▸ PRKAG2 Q9UGJ0 4/20 0.38
▸ PRKAB1 Q9Y478 4/20 0.38
▸ AKR1C4 P17516 1/20 0.38
▸ AKR1C3 P42330 1/20 0.38
▸ AKR1C2 P52895 1/20 0.38
▸ AKR1C1 Q04828 1/20 0.38
▸ KDM5A P29375 1/20 0.37
▸ KDM4C Q9H3R0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30993716 0.83 CREBBP (0.41) F7F3NHERF1NR4A2
SCHEMBL31022995 0.83 NR4A2 (0.57) NR4A2
SCHEMBL30416712 0.82 F7 (0.54) F7F3CSNK2A2CSNK2BCSNK2A1
SCHEMBL22462503 0.82 AKR1C4 (0.48) F7F3CSNK2A2CSNK2BCSNK2A1
SCHEMBL23623627 0.82 F7 (0.54) F7F3CSNK2A2CSNK2BCSNK2A1
SCHEMBL31375034 0.79 F7 (0.51) F7F3CSNK2A2CSNK2BCSNK2A1
SCHEMBL20605026 0.79 MYC (0.47) F7F3CSNK2A2CSNK2BCSNK2A1
SCHEMBL17417782 0.75 F7 (0.50) F7F3CSNK2A2CSNK2BCSNK2A1
SCHEMBL20604918 0.74 CYP1A2 (0.46) CYP3A4CYP1A2
SCHEMBL2425476 0.72 ERN1 (0.47) CYP1A2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230127839-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2023-04-27 — — US disclosed
US-20230127839-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2023-04-27 — — US disclosed
WO-2021138434-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC. (US) 2021-07-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230127839-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 F7 4066/4885F3 4163/4885CSNK2A2 715/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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