Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28843968 | 0.84 | MAPT (0.49) | MAPTTSHRMAPK1POLBHTT | |
| SCHEMBL23624990 | 0.84 | POLB (0.42) | MAPTTSHRMAPK1POLB | |
| SCHEMBL23625109 | 0.84 | ALDH1A1 (0.47) | MAPTTSHRMAPK1POLBHTT | |
| SCHEMBL23625106 | 0.84 | PDE4A (0.33) | MAPTTSHRMAPK1POLBALDH1A1 | |
| SCHEMBL23625107 | 0.81 | ALDH1A1 (0.38) | POLBALDH1A1GAA | |
| SCHEMBL23624986 | 0.80 | BRD4 (0.37) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3259829 | 0.80 | TSHR (0.68) | MAPTTSHRMAPK1POLBHTT | |
| SCHEMBL23624934 | 0.79 | MAPT (0.52) | MAPTTSHRMAPK1POLBHTT | |
| SCHEMBL28144975 | 0.79 | MAPT (0.47) | MAPTTSHRMAPK1POLBHTT | |
| SCHEMBL23625227 | 0.77 | FYN (0.36) | TSHRMAPK1POLBPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021138392-A1 | AMINOPYRIMIDINE COMPOUNDS | TYRA BIOSCIENCES, INC. (US) | 2021-07-08 | — | — | WO | disclosed |