Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.63 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.63 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.63 |
| ▸ | KDR | P35968 | 7/20 | 0.61 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23753626 | 0.96 | KDR (0.67) | RETMAP3K20RIPK3KDRNPC1 | |
| SCHEMBL31362681 | 0.81 | RET (0.59) | RETMAP3K20RIPK3KDRNPC1 | |
| SCHEMBL28384594 | 0.79 | RAB9A (0.65) | RETMAP3K20RIPK3KDRNPC1 | |
| SCHEMBL28235245 | 0.79 | ALDH1A1 (0.65) | RETMAP3K20RIPK3KDRNPC1 | |
| SCHEMBL31362666 | 0.79 | ALDH1A1 (0.65) | RETMAP3K20RIPK3KDRNPC1 | |
| Rivoceranib SCHEMBL1814966 | 0.77 | RET (1.00) | RETMAP3K20RIPK3KDRNPC1 | |
| Rivoceranib SCHEMBL29360856 | 0.77 | RET (1.00) | RETMAP3K20RIPK3KDRNPC1 | |
| SCHEMBL3115333 | 0.77 | KMT2A (0.46) | KDRNPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL6014666 | 0.77 | RET (0.98) | RETMAP3K20RIPK3KDRNPC1 | |
| SCHEMBL3115288 | 0.77 | NAMPT (0.49) | KDRNPC1RAB9AKMT2APRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3847164-A1 | NEW CRYSTALLINE POLYMORPHS OF RIVOCERANIB AND RIVOCERANIB MESYLATE | Assia Chemical Industries Ltd (IL) | 2021-07-14 | — | — | EP | disclosed |