Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 12/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967943 | 0.84 | TAAR1 (0.54) | TAAR1HTR2ASMN1; SMN2CYP2A6LOXL2 | |
| SCHEMBL30937520 | 0.82 | TAAR1 (0.37) | TAAR1HTR2ASMN1; SMN2LOXL2CYP3A4 | |
| SCHEMBL1398159 | 0.82 | TAAR1 (0.37) | TAAR1HTR2ASMN1; SMN2LOXL2CYP3A4 | |
| SCHEMBL20600227 | 0.81 | TDP1 (0.33) | TAAR1SMN1; SMN2CYP3A4TSHRALDH1A1 | |
| SCHEMBL20558456 | 0.78 | TAAR1 (0.59) | TAAR1HTR2ASMN1; SMN2CYP2A6LOXL2 | |
| SCHEMBL14253791 | 0.77 | CYP3A4 (0.36) | TAAR1SMN1; SMN2CYP3A4TSHRALDH1A1 | |
| SCHEMBL6911045 | 0.77 | TAAR1 (0.47) | TAAR1HTR2ASMN1; SMN2CYP2A6LOXL2 | |
| SCHEMBL29037467 | 0.76 | CYP3A4 (0.35) | TAAR1SMN1; SMN2CYP3A4TSHRALDH1A1 | |
| SCHEMBL1372190 | 0.76 | GABRA1 (0.35) | TAAR1SMN1; SMN2CYP3A4TSHRALDH1A1 | |
| SCHEMBL6204770 | 0.76 | GABRA1 (0.39) | TAAR1SMN1; SMN2CYP3A4TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548884-B2 | Cyclic amidine compounds for the treatment of autoimmune disease | HOFFMANN-LA ROCHE INC. (US) | 2023-01-10 | — | — | US | disclosed |
| EP-3847170-B1 | NOVEL CYCLIC AMIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN LA ROCHE (CH) | 2022-06-22 | — | — | EP | disclosed |
| EP-3847170-B1 | NOVEL CYCLIC AMIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN LA ROCHE (CH) | 2022-06-22 | — | — | EP | disclosed |
| US-20210340134-A1 | CYCLIC AMIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2021-11-04 | — | — | US | disclosed |
| EP-3847170-A1 | NOVEL CYCLIC AMIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2021-07-14 | — | — | EP | disclosed |
| CN-112654618-A | Novel cyclic amidine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2021-04-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11548884-B2 | Cyclic amidine compounds for the treatment of autoimmune disease | TLR9, TLR7, TLR8 | TAAR1 106/4885HTR2A 2152/4885SMN1; SMN2 2258/4885 |
| US-20210340134-A1 | CYCLIC AMIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | TLR9, TLR7, TLR8 | TAAR1 106/4885HTR2A 2152/4885SMN1; SMN2 2258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.