SCHEMBL8967943

SCHEMBL8967943

NCCc1c(N)cccc1N

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 13/20 0.54
SMN1; SMN2 Q16637 2/20 0.42
LOXL2 Q9Y4K0 2/20 0.42
CYP2A6 P11509 1/20 0.42
HTR2A P28223 1/20 0.42
CYP3A4 P08684 3/20 0.41
TSHR P16473 2/20 0.41
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
ALOX15 P16050 1/20 0.40
CASP1 P29466 1/20 0.40
CASP7 P55210 1/20 0.40
PIK3CA P42336 1/20 0.39
DRD2 P14416 1/20 0.38
DRD1 P21728 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23629145 0.84 TAAR1 (0.48) TAAR1SMN1; SMN2LOXL2CYP2A6HTR2A
SCHEMBL1823532 0.76 TDP1 (0.40) TAAR1SMN1; SMN2CYP3A4TSHRALDH1A1
SCHEMBL3697918 0.76 CYP3A4 (0.43) SMN1; SMN2CYP3A4TSHRALDH1A1HPGD
Hydrochloric Acid SCHEMBL460781 0.74 CYP3A4 (0.43) TAAR1SMN1; SMN2LOXL2HTR2ACYP3A4
SCHEMBL29592386 0.74 CYP3A4 (0.56) TAAR1SMN1; SMN2CYP2A6HTR2ACYP3A4
SCHEMBL733614 0.74 CYP3A4 (0.56) TAAR1SMN1; SMN2CYP2A6HTR2ACYP3A4
SCHEMBL5250007 0.73 CYP3A4 (0.47) SMN1; SMN2CYP3A4TSHRALDH1A1HPGD
SCHEMBL6085227 0.72 TAAR1 (0.71) TAAR1SMN1; SMN2LOXL2CYP2A6HTR2A
SCHEMBL6959096 0.72 TAAR1 (0.54) TAAR1SMN1; SMN2LOXL2CYP2A6HTR2A
SCHEMBL1952602 0.72 TLR8 (0.39) TAAR1CYP2A6CYP3A4TSHRPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114728998-A Sulfonamide compounds targeting CD73 and adenosine receptors 奥瑞基尼探索技术有限公司 2022-07-08 CN disclosed
EP-0509149-B1 Thermal dye sublimation transfer receiving element AGFA GEVAERT NV (BE) 1996-03-13 EP disclosed
US-5284815-A Image-receiving layer containing an isocyanate-based polymer having a crosslinked and cured surface; dyeability; releasability from the dye donor element AGFA-GEVAERT, N.V. (BE) 1994-02-08 US disclosed
EP-0509149-A1 Thermal dye sublimation transfer receiving element AGFA-GEVAERT N.V. (BE) 1992-10-21 EP disclosed