Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.54 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25281395 | 1.00 | CHRNB2 (0.54) | CHRNB2CHRNA5CHRNA7CHRNA4NPC1 | |
| SCHEMBL25694074 | 0.84 | CHRNB2 (0.50) | CHRNB2CHRNA5CHRNA7CHRNA4NPC1 | |
| SCHEMBL25694076 | 0.84 | CHRNB2 (0.50) | CHRNB2CHRNA5CHRNA7CHRNA4NPC1 | |
| SCHEMBL23629606 | 0.76 | CHRNB2 (0.52) | CHRNB2CHRNA5CHRNA7CHRNA4NPC1 | |
| SCHEMBL22462730 | 0.75 | ABCB1 (0.41) | — | |
| SCHEMBL17959617 | 0.72 | SMYD2 (0.39) | NPC1MEN1KMT2ARAB9A | |
| SCHEMBL532785 | 0.72 | CARM1 (0.61) | CHRNB2CHRNA5CHRNA7CHRNA4CARM1 | |
| SCHEMBL8447322 | 0.72 | CARM1 (0.61) | CHRNB2CHRNA5CHRNA7CHRNA4CARM1 | |
| SCHEMBL8937065 | 0.72 | CHRNB2 (0.50) | CHRNB2CHRNA5CHRNA7CHRNA4NPC1 | |
| SCHEMBL8937063 | 0.72 | CHRNB2 (0.50) | CHRNB2CHRNA5CHRNA7CHRNA4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023114200-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS AND INTERMEDIATES THEREOF | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
| EP-3847174-A1 | MORPHIC FORMS OF COMPLEMENT FACTOR D INHIBITORS | Achillion Pharmaceuticals, Inc. (US) | 2021-07-14 | — | — | EP | disclosed |