Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.52 |
| ▸ | CHRNA5 | P30532 | 3/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | PPM1B | O75688 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30466112 | 0.86 | CHRNB2 (0.46) | CHRNB2CHRNA5CHRNA7CHRNA4FOLH1 | |
| SCHEMBL30466123 | 0.85 | CHRNB2 (0.46) | CHRNB2CHRNA5CHRNA7CHRNA4FOLH1 | |
| SCHEMBL23629617 | 0.76 | CHRNB2 (0.54) | CHRNB2CHRNA5CHRNA7CHRNA4FOLH1 | |
| SCHEMBL25281395 | 0.76 | CHRNB2 (0.54) | CHRNB2CHRNA5CHRNA7CHRNA4FOLH1 | |
| SCHEMBL23629616 | 0.74 | CHRNB2 (0.52) | CHRNB2CHRNA5CHRNA7CHRNA4NPC1 | |
| SCHEMBL30466113 | 0.73 | CHRNB2 (0.54) | CHRNB2CHRNA5CHRNA7CHRNA4NPC1 | |
| SCHEMBL25281113 | 0.73 | CHRNB2 (0.54) | CHRNB2CHRNA5CHRNA7CHRNA4NPC1 | |
| SCHEMBL19615663 | 0.71 | CHRNB2 (0.52) | CHRNB2CHRNA5CHRNA7CHRNA4FOLH1 | |
| SCHEMBL18588004 | 0.71 | CHRNB2 (0.52) | CHRNB2CHRNA5CHRNA7CHRNA4FOLH1 | |
| SCHEMBL18587701 | 0.71 | CHRNB2 (0.52) | CHRNB2CHRNA5CHRNA7CHRNA4FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023114200-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS AND INTERMEDIATES THEREOF | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
| EP-3847174-A1 | MORPHIC FORMS OF COMPLEMENT FACTOR D INHIBITORS | Achillion Pharmaceuticals, Inc. (US) | 2021-07-14 | — | — | EP | disclosed |