Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.30 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.30 |
| ▸ | CFD | P00746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20488109 | 0.88 | LMNA (0.41) | LMNAKDM4EMEN1MAPK1KMT2A | |
| SCHEMBL26679703 | 0.87 | LMNA (0.40) | LMNAKDM4EMEN1NPC1MAPK1 | |
| SCHEMBL23629634 | 0.87 | LMNA (0.37) | LMNAKDM4EMEN1NPC1MAPK1 | |
| SCHEMBL20488553 | 0.86 | LMNA (0.33) | LMNAKDM4EMEN1NPC1MAPK1 | |
| SCHEMBL26679590 | 0.85 | LMNA (0.35) | LMNAKDM4EMEN1NPC1MAPK1 | |
| SCHEMBL26679683 | 0.85 | MTNR1A (0.31) | — | |
| SCHEMBL20487966 | 0.85 | LMNA (0.37) | LMNAMEN1KMT2APTGDR2CFD | |
| SCHEMBL20487312 | 0.84 | LMNA (0.38) | LMNAMEN1KMT2APTGDR2CFD | |
| SCHEMBL26679658 | 0.84 | LMNA (0.35) | LMNAKDM4EMEN1NPC1MAPK1 | |
| SCHEMBL26679665 | 0.84 | MAPT (0.36) | LMNAKDM4EMEN1NPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3846803-A2 | MACROCYCLIC COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS | Achillion Pharmaceuticals, Inc. (US) | 2021-07-14 | — | — | EP | disclosed |