Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cephapirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.98 |
| ▸ | MAPT | P10636 | 8/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.98 |
| ▸ | LMNA | P02545 | 4/20 | 0.98 |
| ▸ | APEX1 | P27695 | 4/20 | 0.98 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.98 |
| ▸ | POLB | P06746 | 3/20 | 0.98 |
| ▸ | RECQL | P46063 | 2/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.83 |
| ▸ | BLM | P54132 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | PKM | P14618 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cephapirin SCHEMBL9437558 | 0.99 | TDP1 (1.00) | TDP1MAPTHSD17B10CYP3A4KDM4E | |
| Cephapirin SCHEMBL64430 | 0.99 | TDP1 (1.00) | TDP1MAPTHSD17B10CYP3A4KDM4E | |
| Cephapirin SCHEMBL28121684 | 0.92 | TDP1 (0.86) | TDP1MAPTHSD17B10CYP3A4KDM4E | |
| Cephapirin SCHEMBL9437555 | 0.92 | NR1I2 (0.98) | TDP1MAPTHSD17B10CYP3A4KDM4E | |
| Cephapirin SCHEMBL151779 | 0.92 | NR1I2 (0.98) | TDP1MAPTHSD17B10CYP3A4KDM4E | |
| Cephapirin SCHEMBL8194062 | 0.91 | NR1I2 (1.00) | TDP1MAPTHSD17B10CYP3A4KDM4E | |
| Cephapirin SCHEMBL11844793 | 0.91 | NR1I2 (1.00) | TDP1MAPTHSD17B10CYP3A4KDM4E | |
| Cephapirin SCHEMBL16072823 | 0.91 | NR1I2 (1.00) | TDP1MAPTHSD17B10CYP3A4KDM4E | |
| Cephapirin SCHEMBL3205 | 0.91 | NR1I2 (1.00) | TDP1MAPTHSD17B10CYP3A4KDM4E | |
| Cephapirin SCHEMBL11844804 | 0.91 | NR1I2 (1.00) | TDP1MAPTHSD17B10CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3846778-A1 | ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES | Aquestive Therapeutics, Inc. (US) | 2021-07-14 | — | — | EP | disclosed |