Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cephapirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 3/20 | 0.98 |
| ▸ | MAPT | P10636 | 8/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.83 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.83 |
| ▸ | POLB | P06746 | 3/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.83 |
| ▸ | APEX1 | P27695 | 2/20 | 0.83 |
| ▸ | LMNA | P02545 | 2/20 | 0.83 |
| ▸ | RECQL | P46063 | 1/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.83 |
| ▸ | CA5A | P35218 | 1/20 | 0.76 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.65 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.65 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.65 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.65 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.65 |
| ▸ | ESR1 | P03372 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cephapirin SCHEMBL151779 | 1.00 | NR1I2 (0.98) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL8194062 | 0.99 | NR1I2 (1.00) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL3205 | 0.99 | NR1I2 (1.00) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL11844804 | 0.99 | NR1I2 (1.00) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL11844793 | 0.99 | NR1I2 (1.00) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL16072823 | 0.99 | NR1I2 (1.00) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL28932665 | 0.98 | NR1I2 (0.98) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL10275188 | 0.93 | NR1I2 (0.88) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL23630215 | 0.92 | TDP1 (0.98) | NR1I2MAPTTDP1CYP3A4L3MBTL1 | |
| Cephapirin SCHEMBL4190569 | 0.91 | NR1I2 (0.84) | NR1I2MAPTTDP1CYP3A4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3846778-A1 | ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES | Aquestive Therapeutics, Inc. (US) | 2021-07-14 | — | — | EP | disclosed |
| US-5342612-A | Potentiating or safening amount of aqueous surfactant with tumor necrosis factor | AMERICAN CYANAMID COMPANY (US) | 1994-08-30 | — | — | US | disclosed |