Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 3/20 | 0.59 |
| ▸ | SMARCA4 | P51532 | 3/20 | 0.59 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.44 |
| ▸ | HTR3B | O95264 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL29943918 | 0.89 | SMARCA2 (0.49) | SMARCA2SMARCA4PBRM1KDM4EHTR3E | |
| SCHEMBL30498705 | 0.86 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1KDM4EHTR3E | |
| SCHEMBL25229903 | 0.86 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1KDM4EHTR3E | |
| SCHEMBL23630323 | 0.80 | SMARCA2 (0.44) | SMARCA2SMARCA4PBRM1KDM4EHSP90AA1 | |
| SCHEMBL31382412 | 0.78 | HSD11B1 (0.43) | SMARCA2SMARCA4PBRM1KDM4ECHRNB2 | |
| SCHEMBL31570178 | 0.76 | SMARCA2 (0.57) | SMARCA2SMARCA4PBRM1KDM4EHTR3E | |
| SCHEMBL26888980 | 0.76 | SMARCA2 (0.57) | SMARCA2SMARCA4PBRM1KDM4EHTR3E | |
| SCHEMBL26685303 | 0.76 | SMARCA2 (0.57) | SMARCA2SMARCA4PBRM1KDM4EHTR3E | |
| Hydrochloric Acid SCHEMBL31382046 | 0.76 | SMARCA2 (0.40) | SMARCA2SMARCA4PBRM1KDM4ENR1I2 | |
| SCHEMBL31382211 | 0.76 | RAF1 (0.38) | SMARCA2SMARCA4PBRM1KDM4ENR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230091042-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2023-03-23 | — | — | US | disclosed |
| EP-4087658-A1 | SMARCA2-VHL DEGRADERS | Amgen Inc. (US) | 2022-11-16 | — | — | EP | disclosed |
| WO-2021142247-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2021-07-15 | — | — | WO | disclosed |
| WO-2021142247-A1 | SMARCA2-VHL DEGRADERS | AMGEN INC. (US) | 2021-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230091042-A1 | SMARCA2-VHL DEGRADERS | VHL, SMARCC2, SMARCC1 | SMARCA2 4/4885SMARCA4 9/4885PBRM1 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.