Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.53 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.53 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25229903 | 1.00 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1ACVR1FYN | |
| SCHEMBL30741489 | 0.88 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1KDM4E | |
| SCHEMBL30741495 | 0.87 | GABRG2 (0.51) | ACVR1BMPR1BACVRL1TGFBR1RPS6KA3 | |
| SCHEMBL23630352 | 0.86 | SMARCA2 (0.59) | SMARCA2SMARCA4PBRM1KDM4EHSP90AA1 | |
| SCHEMBL30498694 | 0.83 | MAP4K1 (0.41) | SMARCA2SMARCA4PBRM1ACVR1FYN | |
| SCHEMBL22791765 | 0.82 | HDAC1 (0.47) | SMARCA2SMARCA4PBRM1HSP90AA1CCNC | |
| SCHEMBL30741492 | 0.81 | ACVR1 (0.46) | ACVR1BMPR1BACVRL1TGFBR1ACVR1B | |
| SCHEMBL30741493 | 0.81 | ACVR1 (0.46) | ACVR1BMPR1BACVRL1TGFBR1KDR | |
| SCHEMBL25348542 | 0.81 | SMARCA2 (0.70) | SMARCA2SMARCA4PBRM1ACVR1FYN | |
| SCHEMBL28469016 | 0.80 | ADRB1 (0.56) | SMARCA2SMARCA4PBRM1ACVR1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116529250-A | 6-substituted pyridazine compounds as SMARCA2 and/or SMARCA4 degrading agents | 奥里吉恩肿瘤学有限公司 | 2023-08-01 | — | — | CN | disclosed |