Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | PRKACG | P22612 | 1/20 | 0.53 |
| ▸ | PRKACB | P22694 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23630313 | 0.85 | PRKACA (0.57) | PRKACAPRKACGPRKACBRXFP1AOC3 | |
| SCHEMBL23630334 | 0.83 | PRKACA (0.58) | PRKACAPRKACGPRKACBRXFP1NPC1 | |
| SCHEMBL23630397 | 0.72 | AOC3 (0.38) | RXFP1NPC1RAB9AHTR2CAOC3 | |
| SCHEMBL9933248 | 0.71 | PRKACA (1.00) | PRKACAPRKACGPRKACBRXFP1NPC1 | |
| SCHEMBL23630439 | 0.70 | GRM2 (0.38) | RXFP1NPC1RAB9AHTR2CAOC3 | |
| SCHEMBL16447505 | 0.70 | CYP3A4 (0.56) | HTR2CAOC3KDM4EP2RY14TP53 | |
| SCHEMBL13717673 | 0.70 | PRKACA (0.97) | PRKACAPRKACGPRKACBRXFP1NPC1 | |
| SCHEMBL10925763 | 0.69 | MYC (0.48) | RXFP1NPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL1440040 | 0.68 | PRKACA (0.73) | PRKACAPRKACGPRKACBRXFP1NPC1 | |
| SCHEMBL23630395 | 0.66 | PRKACA (0.57) | PRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021142420-A1 | PYRAZOLO[1,5-a]PYRIMIDIN-7(4H)-ONE INHIBITORS OF DYNEIN | KAPOOR TARUN M (US) | 2021-07-15 | — | — | WO | disclosed |
| WO-2021142420-A1 | PYRAZOLO[1,5-a]PYRIMIDIN-7(4H)-ONE INHIBITORS OF DYNEIN | KAPOOR TARUN M (US) | 2021-07-15 | — | — | WO | disclosed |