Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | PRKACG | P22612 | 1/20 | 0.57 |
| ▸ | PRKACB | P22694 | 1/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.45 |
| ▸ | CHIT1 | Q13231 | 2/20 | 0.44 |
| ▸ | CHIA | Q9BZP6 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23630368 | 0.85 | PRKACA (0.53) | PRKACAPRKACGPRKACBGRM2MAPT | |
| SCHEMBL20564864 | 0.80 | ALDH1A1 (0.37) | PRKACAPRKACGPRKACBGRM2CHIT1 | |
| SCHEMBL23630311 | 0.78 | ALDH1A1 (0.43) | PRKACAPRKACGPRKACBGRM2CHIT1 | |
| SCHEMBL9933248 | 0.74 | PRKACA (1.00) | PRKACAPRKACGPRKACBMAPTKDM4E | |
| SCHEMBL13717673 | 0.72 | PRKACA (0.97) | PRKACAPRKACGPRKACBMAPTKDM4E | |
| SCHEMBL1440040 | 0.70 | PRKACA (0.73) | PRKACAPRKACGPRKACBMAPTKDM4E | |
| SCHEMBL22324960 | 0.68 | DRD2 (0.45) | GRM2CHIT1CHIAMAPTNPSR1 | |
| SCHEMBL20565565 | 0.68 | GRM2 (0.45) | GRM2MAPTKDM4ENPSR1HPGD | |
| SCHEMBL23635380 | 0.67 | GRM2 (0.44) | GRM2MAPTKDM4ENPSR1HPGD | |
| SCHEMBL2017867 | 0.67 | PANK3 (0.57) | GRM2DRD2SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021142420-A1 | PYRAZOLO[1,5-a]PYRIMIDIN-7(4H)-ONE INHIBITORS OF DYNEIN | KAPOOR TARUN M (US) | 2021-07-15 | — | — | WO | disclosed |
| WO-2021142420-A1 | PYRAZOLO[1,5-a]PYRIMIDIN-7(4H)-ONE INHIBITORS OF DYNEIN | KAPOOR TARUN M (US) | 2021-07-15 | — | — | WO | disclosed |