Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10063585 | 0.78 | CCR1 (0.54) | CCR1KDM4EALDH1A1CSNK1A1TYRO3 | |
| SCHEMBL10063594 | 0.76 | CCR1 (0.41) | CCR1ALDH1A1NAMPTMTORADK | |
| SCHEMBL1639566 | 0.74 | CCR1 (0.53) | CCR1KDM4EALDH1A1CSNK1A1TYRO3 | |
| SCHEMBL1846819 | 0.74 | ABL1 (0.38) | MTOR | |
| SCHEMBL1638721 | 0.73 | CCR1 (0.52) | CCR1KDM4EALDH1A1TRPV1KMT2A | |
| SCHEMBL18058868 | 0.71 | CCR1 (0.50) | CCR1KDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL20530284 | 0.69 | MEN1 (0.37) | KDM4EELANEMEN1KMT2AHTT | |
| SCHEMBL13978836 | 0.67 | CCR1 (0.62) | CCR1KDM4EALDH1A1 | |
| SCHEMBL27714803 | 0.64 | MAOB (0.39) | KDM4EELANEMAP2K1CYP3A4ALOX12 | |
| SCHEMBL9996736 | 0.64 | FAAH (0.45) | KDM4EALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101743238-B | 3-(imidazolyl)-pyrazolo[3,4-b]pyridines | CHEMOCENTRYX INC | 2014-04-30 | — | — | CN | disclosed |
| EP-2352501-A1 | COMPOUNDS FOR THE TREATMENT OF OSTEOPOROSIS AND CANCERS | ChemoCentryx, Inc. (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2010051561-A1 | COMPOUNDS FOR THE TREATMENT OF OSTEOPOROSIS AND CANCERS | CHEMOCENTRYX, INC. (US) | 2010-05-06 | — | — | WO | disclosed |
| EP-2155712-A1 | 3-(IMIDAZOLYL)-PYRAZOLOÝ3,4-B¨PYRIDINES | ChemoCentryx Inc (US) | 2010-02-24 | — | — | EP | disclosed |
| EP-2155203-A1 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | ChemoCentryx Inc (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008147815-A1 | 3-(IMIDAZOLYL)-PYRAZOLO[3,4-B]PYRIDINES | CHEMOCENTRYX, INC. (US) | 2008-12-04 | — | — | WO | disclosed |
| WO-2008147822-A1 | AZAINDAZOLE COMPOUNDS AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2008-12-04 | — | — | WO | disclosed |