Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 4/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 4/20 | 0.36 |
| ▸ | LPL | P06858 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | LIPC | P11150 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23632822 | 1.00 | ACACB (0.37) | ACACBSCN9AEPHX2LIPGLPL | |
| SCHEMBL23632206 | 0.91 | EPHX2 (0.39) | ACACBSCN9AEPHX2LIPGLPL | |
| SCHEMBL23632894 | 0.91 | EPHX2 (0.39) | ACACBSCN9AEPHX2LIPGLPL | |
| SCHEMBL28601527 | 0.91 | ACACB (0.44) | ACACBSCN9AEPHX2LIPGLPL | |
| SCHEMBL23632833 | 0.90 | PRKAA2 (0.41) | ACACBSCN9AEPHX2LIPGLPL | |
| SCHEMBL23633131 | 0.90 | PRKAA2 (0.41) | ACACBSCN9AEPHX2LIPGLPL | |
| SCHEMBL23632613 | 0.86 | EPHX2 (0.42) | EPHX2LIPGLIPCLIPEFFAR1 | |
| SCHEMBL23632256 | 0.86 | EPHX2 (0.42) | EPHX2LIPGLIPCLIPEFFAR1 | |
| SCHEMBL23632735 | 0.85 | ACACB (0.38) | ACACBSCN9AEPHX2LIPGLPL | |
| SCHEMBL28529263 | 0.85 | RBP4 (0.38) | ACACBRBP4GRM4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021139599-A1 | RORγT INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 东莞市东阳光新药研发有限公司 | 2021-07-15 | — | — | WO | disclosed |
| CN-113072476-A | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业有限公司 | 2021-07-06 | — | — | CN | disclosed |