Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25408602 | 0.88 | EPHX2 (0.50) | CYP11B1CYP11B2GAARAB9AFAAH | |
| SCHEMBL25413272 | 0.86 | BRD4 (0.51) | CYP11B1CYP11B2GAARAB9AFAAH | |
| SCHEMBL30614188 | 0.86 | BRD4 (0.51) | CYP11B1CYP11B2GAARAB9AFAAH | |
| SCHEMBL31632909 | 0.85 | EPHX2 (0.61) | CYP11B1CYP11B2EPHX2PPARGEGFR | |
| SCHEMBL23632012 | 0.85 | AGTR1 (0.50) | EPHX2PPARGHTR2AHTR2CTP53 | |
| SCHEMBL16596018 | 0.84 | EPHX2 (0.47) | CYP11B1CYP11B2EPHX2PPARGHDAC2 | |
| SCHEMBL1418153 | 0.83 | HDAC6 (0.51) | GAARAB9AFAAHEPHX2PPARG | |
| SCHEMBL25411989 | 0.83 | GAA (0.48) | CYP11B1CYP11B2GAARAB9AFAAH | |
| SCHEMBL16056414 | 0.83 | CYP11B1 (0.50) | CYP11B1CYP11B2GAARAB9AEPHX2 | |
| SCHEMBL3724300 | 0.83 | RECQL (0.60) | GAARAB9AFAAHMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072542-B | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| WO-2021139595-A1 | RORγT INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 东莞市东阳光新药研发有限公司 | 2021-07-15 | — | — | WO | disclosed |
| CN-113072542-A | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业有限公司 | 2021-07-06 | — | — | CN | disclosed |