Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.46 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1747966 | 0.95 | DGAT1 (0.47) | DGAT1CSGALNACT1DYRK1AFSCN1MAPT | |
| Trifluoroacetic Acid SCHEMBL2363935 | 0.88 | DGAT1 (0.43) | DGAT1CSGALNACT1DYRK1AMAPTALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL2363933 | 0.88 | DGAT1 (0.43) | DGAT1CSGALNACT1DYRK1AMAPTALDH1A1 | |
| SCHEMBL1748025 | 0.86 | DGAT1 (0.49) | DGAT1CSGALNACT1DYRK1AFSCN1TRPV1 | |
| Trifluoroacetic Acid SCHEMBL2363691 | 0.84 | NPC1 (0.43) | DGAT1CSGALNACT1DYRK1AMAPTALDH1A1 | |
| SCHEMBL2307751 | 0.83 | DGAT1 (0.49) | DGAT1CSGALNACT1DYRK1AFSCN1TRPV1 | |
| SCHEMBL2306954 | 0.82 | KMT2A (0.46) | DGAT1CSGALNACT1DYRK1AMAPTALDH1A1 | |
| SCHEMBL1748280 | 0.82 | DGAT1 (0.45) | DGAT1CSGALNACT1DYRK1AFSCN1TRPV1 | |
| SCHEMBL2306757 | 0.79 | NPC1 (0.47) | DGAT1CSGALNACT1DYRK1AMAPTALDH1A1 | |
| SCHEMBL2306840 | 0.78 | DYRK1A (0.48) | DGAT1CSGALNACT1DYRK1AFSCN1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | disclosed |
| US-7423156-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |
| US-7091228-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-08-15 | — | — | US | disclosed |