Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPY1R | P25929 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2363935 | 1.00 | DGAT1 (0.43) | DGAT1CSGALNACT1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2306954 | 0.95 | KMT2A (0.46) | DGAT1CSGALNACT1KMT2ASMN1; SMN2NPC1 | |
| Trifluoroacetic Acid SCHEMBL2363303 | 0.88 | DGAT1 (0.46) | DGAT1CSGALNACT1KMT2ANPC1HTT | |
| SCHEMBL1747966 | 0.82 | DGAT1 (0.47) | DGAT1CSGALNACT1KMT2ASMN1; SMN2NPC1 | |
| Trifluoroacetic Acid SCHEMBL2363691 | 0.82 | NPC1 (0.43) | DGAT1CSGALNACT1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2307188 | 0.80 | DYRK1A (0.52) | DGAT1CSGALNACT1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2306757 | 0.76 | NPC1 (0.47) | DGAT1CSGALNACT1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL1748025 | 0.73 | DGAT1 (0.49) | DGAT1CSGALNACT1NPC1DYRK1AMAPT | |
| SCHEMBL12266255 | 0.73 | LIPG (0.46) | DGAT1CSGALNACT1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2306330 | 0.71 | SCD (0.58) | DGAT1CSGALNACT1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | disclosed |
| US-7423156-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |
| US-7091228-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-08-15 | — | — | US | disclosed |