Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | IDH2 | P48735 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | CTSC | P53634 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14149250 | 0.83 | KIF11 (0.61) | KIF11KDM4EGAAIDH2MAPT | |
| SCHEMBL18827487 | 0.83 | KIF11 (0.66) | KIF11IDH2MAPTKMT2AAURKA | |
| SCHEMBL17396429 | 0.82 | ABL1 (0.50) | APPEGFR | |
| SCHEMBL22212784 | 0.82 | CYP2C9 (0.50) | KMT2AAPPALDH1A1 | |
| SCHEMBL1921482 | 0.81 | KIF11 (0.70) | KIF11GAAIDH2MAPTAURKA | |
| SCHEMBL394991 | 0.81 | KIF11 (0.70) | KIF11KDM4EGAAIDH2MAPT | |
| SCHEMBL17364449 | 0.80 | MAPT (0.71) | KIF11GAAIDH2MAPTMEN1 | |
| SCHEMBL13550150 | 0.80 | KIF11 (0.57) | KIF11KDM4EGAAIDH2MAPT | |
| SCHEMBL14149412 | 0.80 | KIF11 (0.57) | KIF11KDM4EGAAIDH2MAPT | |
| SCHEMBL14541646 | 0.80 | KIF11 (0.57) | KIF11KDM4EGAAIDH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210215671-A1 | COMPOUNDS AND METHODS OF IDENTIFYING, SYNTHESIZING, OPTIMIZING AND PROFILING PROTEIN MODULATORS | HMI Medical Innovations, LLC | 2021-07-15 | — | — | US | disclosed |