Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.39 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23634899 | 0.92 | SIGMAR1 (0.48) | SIGMAR1NUAK1TSHRHRH3MAOB | |
| SCHEMBL23634903 | 0.92 | SIGMAR1 (0.48) | SIGMAR1NUAK1TSHRHRH3MAOB | |
| SCHEMBL23635043 | 0.92 | SIGMAR1 (0.48) | SIGMAR1NUAK1TSHRHRH3MAOB | |
| SCHEMBL23918302 | 0.90 | HRH3 (0.46) | SIGMAR1NUAK1TSHRHRH3MAOB | |
| SCHEMBL23635018 | 0.90 | HRH3 (0.46) | SIGMAR1NUAK1TSHRHRH3MAOB | |
| SCHEMBL23635017 | 0.90 | HRH3 (0.46) | SIGMAR1NUAK1TSHRHRH3MAOB | |
| SCHEMBL23634904 | 0.89 | SIGMAR1 (0.48) | SIGMAR1HRH3MAOBCRBNALDH1A1 | |
| SCHEMBL23634905 | 0.89 | SIGMAR1 (0.48) | SIGMAR1HRH3MAOBCRBNALDH1A1 | |
| SCHEMBL23635019 | 0.88 | DDB1 (0.46) | SIGMAR1CRBNKDM4EALDH1A1PRKDC | |
| SCHEMBL23635016 | 0.88 | DDB1 (0.46) | SIGMAR1CRBNKDM4EALDH1A1PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848363-B1 | TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND | MEDSHINE DISCOVERY INC (CN) | 2023-07-19 | — | — | EP | disclosed |
| EP-3848363-A1 | TRICYCLIC SUBSTITUTED PIPERIDINE DIONE COMPOUND | Medshine Discovery Inc. (CN) | 2021-07-14 | — | — | EP | disclosed |