Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.83 |
| ▸ | DRD3 | P35462 | 11/20 | 0.83 |
| ▸ | DRD4 | P21917 | 7/20 | 0.83 |
| ▸ | HTR1A | P08908 | 4/20 | 0.83 |
| ▸ | HTR2A | P28223 | 4/20 | 0.83 |
| ▸ | HTR2C | P28335 | 4/20 | 0.83 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29799509 | 0.91 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL19358657 | 0.91 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL17066480 | 0.79 | DRD2 (0.80) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL27635353 | 0.76 | HTR1A (0.74) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL24683684 | 0.76 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL14397163 | 0.76 | HTR1A (0.74) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL335802 | 0.75 | HTR1A (0.73) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL31561598 | 0.75 | HTR1A (0.73) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL28078181 | 0.75 | HTR1A (0.73) | DRD2DRD3DRD4HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL11552605 | 0.75 | HTR1A (0.68) | DRD2DRD3DRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848351-A1 | DOPAMINE D3 RECEPTOR SELECTIVE ANTAGONISTS/PARTIAL AGONISTS; METHOD OF MAKING; AND USE THEREOF | The United States of America, as represented by The Secretary, Department of Health and Human Services (US) | 2021-07-14 | — | — | EP | disclosed |