Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24816122 | 0.84 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2NTRK1 | |
| SCHEMBL24329944 | 0.83 | NPC1 (0.49) | NPC1RAB9AMAPTSMN1; SMN2TLR8 | |
| SCHEMBL23638355 | 0.80 | NPC1 (0.44) | NPC1RAB9AMAPTSMN1; SMN2NTRK1 | |
| SCHEMBL13777230 | 0.80 | RAB9A (0.49) | NPC1RAB9AMAPTSMN1; SMN2TLR8 | |
| SCHEMBL23638515 | 0.80 | RAB9A (0.49) | NPC1RAB9AMAPTSMN1; SMN2NTRK1 | |
| SCHEMBL23638517 | 0.79 | NPC1 (0.46) | NPC1RAB9AMAPTSMN1; SMN2TLR8 | |
| SCHEMBL28038284 | 0.78 | MAPT (0.67) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL25539221 | 0.78 | PDE10A (0.46) | NPC1RAB9AMAPTSMN1; SMN2NTRK1 | |
| SCHEMBL23638286 | 0.77 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2TLR8 | |
| SCHEMBL24816119 | 0.77 | MAPT (0.53) | NPC1RAB9AMAPTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021139775-A1 | PYRIDONE COMPOUND AND APPLICATION | 江苏先声药业有限公司 | 2021-07-15 | — | — | WO | disclosed |