Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23638356 | 0.83 | NPC1 (0.47) | NPC1RAB9ATLR8MAPTSMN1; SMN2 | |
| SCHEMBL23638515 | 0.83 | RAB9A (0.49) | NPC1RAB9ATLR8MAPTSMN1; SMN2 | |
| SCHEMBL13777230 | 0.83 | RAB9A (0.49) | NPC1RAB9ATLR8MAPTSMN1; SMN2 | |
| SCHEMBL24330834 | 0.81 | MAPT (0.41) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL13604061 | 0.81 | MAPT (0.44) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL24329871 | 0.81 | MAPT (0.45) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL24816119 | 0.80 | MAPT (0.53) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL24816122 | 0.80 | NPC1 (0.47) | NPC1RAB9ATLR8MAPTSMN1; SMN2 | |
| SCHEMBL23638286 | 0.80 | NPC1 (0.47) | NPC1RAB9ATLR8MAPTSMN1; SMN2 | |
| SCHEMBL25539217 | 0.80 | TP53 (0.50) | NPC1RAB9ATLR8MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078403-A1 | SUBSTITUTED PYRIDONE COMPOUND AND APPLICATION | 江苏先声药业有限公司 | 2022-04-21 | — | — | WO | disclosed |