SCHEMBL23638993

SCHEMBL23638993

CC1C=CC=CC1c1cccnc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.46
CHRNB2 P17787 6/20 0.42
CHRNA4 P43681 4/20 0.42
CYP11B2 P19099 1/20 0.42
CHRNA7 P36544 6/20 0.40
CHRNA3 P32297 4/20 0.40
ALDH1A1 P00352 2/20 0.39
CHRNB4 P30926 2/20 0.39
CHRNA2 Q15822 2/20 0.39
LMNA P02545 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
HTR3E A5X5Y0 1/20 0.39
PSIP1 O75475 1/20 0.39
TRPA1 O75762 1/20 0.39
HTR3B O95264 1/20 0.39
CHRNA1 P02708 1/20 0.39
CHRNG P07510 1/20 0.39
MAPT P10636 1/20 0.39
CHRNB1 P11230 1/20 0.39
PTGS1 P23219 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28036409 0.78 CYP2C19 (0.42) CYP2A6CHRNA7LMNACYP2A13
SCHEMBL12143642 0.75 CYP2A6 (0.66) CYP2A6CHRNB2CHRNA4CYP11B2CHRNA7
SCHEMBL18998469 0.75 CYP2A6 (0.66) CYP2A6CHRNB2CHRNA4CYP11B2CHRNA7
SCHEMBL19121445 0.75 CYP2A6 (0.66) CYP2A6CHRNB2CHRNA4CYP11B2CHRNA7
SCHEMBL11933858 0.69 CHRNB2 (0.47) CYP2A6CHRNB2CHRNA4CYP11B2CHRNA7
SCHEMBL9844930 0.68 CYP2A6 (0.49) CYP2A6CHRNB2CHRNA4CYP11B2CHRNA7
SCHEMBL19059998 0.68 CYP2A6 (0.40) CYP2A6CHRNB2CHRNA4CYP11B2CHRNA7
SCHEMBL29804975 0.68 CHRNB2 (0.56) CYP2A6CHRNB2CHRNA4CYP11B2CHRNA7
SCHEMBL27956069 0.68 CYP2A6 (0.56) CYP2A6CHRNB2CHRNA4CYP11B2CHRNA7
SCHEMBL19048919 0.68 GAA (0.37) ALDH1A1LMNATDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3277677-B9 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS MISSION THERAPEUTICS LTD (GB) 2021-07-14 EP disclosed