Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 10/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | GRB2 | P62993 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HNF4A | P41235 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23640325 | 0.85 | MAPT (0.49) | MAPTAKR1B1SMN1; SMN2KDM4E | |
| SCHEMBL23640304 | 0.85 | MAPT (0.49) | MAPTAKR1B1THRBSMN1; SMN2KDM4E | |
| SCHEMBL23639978 | 0.83 | ALDH1A1 (0.43) | MAPTESR1ESR2AKR1B1SMN1; SMN2 | |
| SCHEMBL9036818 | 0.80 | MAPT (0.70) | MAPTESR1ESR2LCKFYN | |
| SCHEMBL24939758 | 0.80 | MAPT (0.57) | MAPTESR1ESR2LCKFYN | |
| SCHEMBL24302589 | 0.76 | MAPT (0.50) | MAPTESR1ESR2THRBSMN1; SMN2 | |
| SCHEMBL24950261 | 0.74 | KDM4E (0.68) | MAPTLCKFYNAKR1B1GRB2 | |
| SCHEMBL23640218 | 0.73 | MAPT (0.47) | MAPTAKR1B1SMN1; SMN2KDM4E | |
| SCHEMBL24753979 | 0.73 | SMN1; SMN2 (0.47) | MAPTAKR1B1SMN1; SMN2KDM4E | |
| SCHEMBL11211516 | 0.71 | MAPT (0.50) | MAPTAKR1B1THRBSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119376-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2022-04-21 | — | — | US | disclosed |
| EP-3848367-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119376-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | CRBN, CSNK2A1, CSNK2A2 | MAPT 539/4885ESR1 3760/4885ESR2 2033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.