Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17507545 | 0.91 | ALDH1A1 (0.49) | MAPTMAPK1AHRSMN1; SMN2HTT | |
| SCHEMBL17507492 | 0.90 | KMT2A (0.46) | MAPTMAPK1AHRSMN1; SMN2HTT | |
| SCHEMBL12435912 | 0.89 | HTT (0.44) | MAPTMAPK1AHRSMN1; SMN2HTT | |
| SCHEMBL17507543 | 0.86 | MAPT (0.50) | MAPTHTTKMT2ALMNAALDH1A1 | |
| SCHEMBL2217242 | 0.81 | MAPT (0.56) | MAPTMAPK1AHRSMN1; SMN2HTT | |
| SCHEMBL2359445 | 0.81 | LMNA (0.47) | MAPTMAPK1SMN1; SMN2HTTKMT2A | |
| SCHEMBL17507529 | 0.81 | LMNA (0.47) | MAPTMAPK1SMN1; SMN2HTTKMT2A | |
| SCHEMBL2215369 | 0.81 | MAPT (0.49) | MAPTMAPK1AHRSMN1; SMN2HTT | |
| SCHEMBL17507493 | 0.81 | HTT (0.51) | MAPTMAPK1AHRSMN1; SMN2HTT | |
| SCHEMBL17507533 | 0.80 | ALDH1A1 (0.46) | MAPTSMN1; SMN2HTTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351731-B1 | A GROUP OF AMINO SUBSTITUTED BENZOYL DERIVATIVES AND THEIR PREPARATION AND THEIR USE | INST MED BIOTECHNOLOGY CAMS (CN) | 2016-02-10 | — | — | EP | disclosed |
| US-8710098-B2 | Group of amino substituted benzoyl derivatives and their preparation and their use | Institute of Medicinal Biotechnology Chinese Academy of Medical Science (CN) | 2014-04-29 | — | — | US | disclosed |
| EP-2351731-A1 | A GROUP OF AMINO SUBSTITUTED BENZOYL DERIVATIVES AND THEIR PREPARATION AND THEIR USE | Institute Of Medicinal Biotechnology, Chinese Academy of Medical Sciences (CN) | 2011-08-03 | — | — | EP | disclosed |
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | Institute of Medicinal Biotechnology Academy of Medical Science (CN) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | CUL3, APOBEC3G, BRPF3 | MAPT 3474/4885MAPK1 4279/4885AHR 2192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.