Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24302883 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL14338249 | 0.77 | MTNR1B (0.69) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL23640233 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2RAB9ANPC1MAPK1MTNR1A | |
| SCHEMBL24302885 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2RAB9ANPC1MAPK1MTNR1A | |
| SCHEMBL12888865 | 0.74 | MAPK1 (0.65) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL9162294 | 0.73 | MTNR1B (0.77) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL3183886 | 0.72 | ALDH1A1 (0.72) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL14338254 | 0.72 | MTNR1B (0.61) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL14384855 | 0.72 | HSD17B10 (0.72) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL27588285 | 0.72 | ALDH1A1 (0.56) | SMN1; SMN2RAB9ANPC1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848367-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-07-14 | — | — | EP | disclosed |