Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 3/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9455443 | 0.92 | KMT2A (0.52) | SMN1; SMN2HAO1ALDH1A1GFERKMT2A | |
| SCHEMBL30587868 | 0.92 | KMT2A (0.52) | SMN1; SMN2HAO1ALDH1A1GFERKMT2A | |
| SCHEMBL6438319 | 0.85 | LTA4H (0.54) | SMN1; SMN2ACHELTA4HHAO1ALDH1A1 | |
| SCHEMBL10709191 | 0.85 | SMN1; SMN2 (0.80) | SMN1; SMN2ACHEMTNR1BMTNR1ALTA4H | |
| SCHEMBL29352597 | 0.85 | CA12 (0.53) | ACHEKDM4EHAO1ALDH1A1GFER | |
| SCHEMBL83318 | 0.85 | CA12 (0.53) | ACHEKDM4EHAO1ALDH1A1GFER | |
| SCHEMBL30053231 | 0.85 | SMN1; SMN2 (0.72) | SMN1; SMN2ACHEMTNR1BMTNR1ALTA4H | |
| SCHEMBL29929943 | 0.85 | SMN1; SMN2 (0.72) | SMN1; SMN2ACHEMTNR1BMTNR1ALTA4H | |
| SCHEMBL13167638 | 0.85 | SMN1; SMN2 (0.72) | SMN1; SMN2ACHEMTNR1BMTNR1ALTA4H | |
| SCHEMBL1061713 | 0.85 | SMN1; SMN2 (0.72) | SMN1; SMN2ACHEMTNR1BMTNR1ALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119376-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2022-04-21 | — | — | US | disclosed |
| EP-3848367-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2021-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119376-A1 | TRICYCLIC COMPOUNDS ACTING ON CRBN PROTEINS | CRBN, CSNK2A1, CSNK2A2 | SMN1; SMN2 2099/4885ACHE 4281/4885MTNR1B 2380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.