SCHEMBL2364047

SCHEMBL2364047

C[C@@H](NC(=O)CC(N)=O)C(C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
SIGMAR1 Q99720 1/20 0.41
TAS1R3 Q7RTX0 3/20 0.38
TAS1R1 Q7RTX1 3/20 0.38
TAS1R2 Q8TE23 3/20 0.38
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HPGD P15428 2/20 0.35
ECE1 P42892 4/20 0.34
ALDH1A1 P00352 1/20 0.34
DPP4 P27487 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA7 P43166 1/20 0.32
PIK3CD O00329 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2363846 1.00 CYP3A4 (0.43) CYP3A4CYP2C9CYP2C19SIGMAR1TAS1R3
SCHEMBL13826479 0.80 CYP3A4 (0.44) CYP3A4CYP2C9CYP2C19SIGMAR1TAS1R3
SCHEMBL16298847 0.77 CYP2C9 (0.46) CYP3A4CYP2C9CYP2C19SIGMAR1TAS1R3
SCHEMBL31483043 0.77 CYP2C9 (0.46) CYP3A4CYP2C9CYP2C19SIGMAR1TAS1R3
SCHEMBL24741522 0.77 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19SIGMAR1TAS1R3
SCHEMBL14241689 0.77 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19SIGMAR1TAS1R3
SCHEMBL14729745 0.77 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19SIGMAR1TAS1R3
SCHEMBL21394036 0.77 MEN1 (0.45) CYP2C9CYP2C19MEN1LMNAPOLB
SCHEMBL4850022 0.77 CYP3A4 (0.44) CYP3A4CYP2C9CYP2C19SIGMAR1TAS1R3
SCHEMBL8433156 0.76 CYP3A4 (0.44) CYP3A4CYP2C9CYP2C19SIGMAR1TAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2528902-A1 OXYGEN-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI (FR) 2012-12-05 EP disclosed
WO-2011092187-A1 OXYGEN-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS SANOFI (FR) 2011-08-04 WO disclosed