Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7877735 | 0.87 | ALDH1A1 (0.48) | POLBGAABCHEALDH1A1 | |
| SCHEMBL26003725 | 0.86 | L3MBTL1 (0.40) | L3MBTL1MEN1KMT2ASIGMAR1HRH1 | |
| SCHEMBL10962715 | 0.84 | POLB (0.47) | POLBGAABCHEALDH1A1 | |
| SCHEMBL154270 | 0.84 | ALDH1A1 (0.48) | MEN1KMT2APOLBGAABCHE | |
| SCHEMBL1239442 | 0.84 | L3MBTL1 (0.55) | L3MBTL1MEN1KMT2ASIGMAR1HTR2A | |
| Hydrochloric Acid SCHEMBL1242121 | 0.82 | MEN1 (0.58) | L3MBTL1MEN1KMT2ASIGMAR1HTR2A | |
| Hydrochloric Acid SCHEMBL11203276 | 0.82 | ALDH1A1 (0.47) | POLBGAABCHEALDH1A1 | |
| SCHEMBL17508109 | 0.82 | ALDH1A1 (0.47) | POLBGAABCHEALDH1A1 | |
| SCHEMBL154265 | 0.81 | KCNH2 (0.51) | SIGMAR1APPBCHE | |
| SCHEMBL8987713 | 0.79 | HDAC3 (0.49) | POLBGAABCHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848355-A1 | ASYMMETRIC BISAMINOQUINOLINES AND BISAMINOQUINOLINES WITH VARIED LINKERS AS AUTOPHAGY INHIBITORS FOR CANCER AND OTHER THERAPY | The Trustees Of The University Of Pennsylvania (US) | 2021-07-14 | — | — | EP | disclosed |