Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PI4KA | P42356 | 3/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3217142 | 0.84 | PRMT5 (0.45) | PRMT5WDR77MAPTNPC1PTGS1 | |
| SCHEMBL19311825 | 0.84 | GRIN2B (0.47) | — | |
| SCHEMBL26040044 | 0.84 | PRMT5 (0.46) | PRMT5WDR77PTGS1PTGS2S1PR1 | |
| SCHEMBL12462747 | 0.77 | PRMT5 (0.40) | PRMT5WDR77PTGS1PTGS2PIK3CA | |
| SCHEMBL12083955 | 0.75 | TAAR1 (0.47) | PRMT5WDR77MAP4K4 | |
| SCHEMBL13495562 | 0.75 | GRM5 (0.44) | PRMT5WDR77PTGS1PTGS2PIK3CD | |
| SCHEMBL12190331 | 0.75 | METAP2 (0.43) | PRMT5WDR77MAPTNPC1PTGS1 | |
| SCHEMBL10271458 | 0.75 | RAB9A (0.45) | PRMT5WDR77MAPTNPC1 | |
| SCHEMBL18822208 | 0.75 | PRMT5 (0.41) | PRMT5WDR77PTGS1PTGS2PIK3CA | |
| SCHEMBL10460931 | 0.75 | METAP2 (0.43) | PRMT5WDR77MAPTNPC1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3848368-A1 | TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2021-07-14 | — | — | EP | disclosed |