Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | KDM1A | O60341 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.55 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.52 |
| ▸ | GID4 | Q8IVV7 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30973233 | 1.00 | PRCP (0.67) | PRCPGAAKDM1AMEN1KMT2A | |
| SCHEMBL14677170 | 0.87 | PRCP (0.67) | PRCPGAAKDM1AMEN1KMT2A | |
| SCHEMBL19752317 | 0.85 | PRCP (0.55) | PRCPGAAKDM1AMEN1KMT2A | |
| SCHEMBL29498355 | 0.82 | KDM1A (0.67) | PRCPGAAKDM1AMEN1KMT2A | |
| SCHEMBL19399589 | 0.82 | KDM1A (0.67) | PRCPGAAKDM1AMEN1KMT2A | |
| SCHEMBL2340014 | 0.81 | PRCP (0.67) | PRCPGAAKDM1AMEN1KMT2A | |
| SCHEMBL2364169 | 0.80 | GID4 (0.69) | PRCPGAAKDM1AMEN1KMT2A | |
| SCHEMBL22728763 | 0.80 | PRCP (1.00) | PRCPGAAKDM1AMEN1KMT2A | |
| SCHEMBL7214001 | 0.80 | PRCP (1.00) | PRCPGAAKDM1AMEN1KMT2A | |
| SCHEMBL30973183 | 0.80 | PRCP (1.00) | PRCPGAAKDM1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118146154-A | Method for synergistic catalysis of selective oxidative dehydrogenation of tetrahydroisoquinoline | 西安石油大学 | 2024-06-07 | — | — | CN | disclosed |
| US-8367700-B2 | Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2013-02-05 | — | — | US | disclosed |
| EP-2358681-A1 | SUBSTITUTED 4-(1,2,3,4-TETRAHYDROISOCHINOLIN-2-YL)-4-OXO-BUTYRIC ACID AMIDE AS KCNQ2/2 MODULATORS | Grünenthal GmbH (DE) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010075973-A1 | SUBSTITUTED 4-(1,2,3,4-TETRAHYDROISOCHINOLIN-2-YL)-4-OXO-BUTYRIC ACID AMIDE AS KCNQ2/2 MODULATORS | Grünenthal GmbH (DE) | 2010-07-08 | — | — | WO | disclosed |
| US-20100152234-A1 | Substituted 4-(1,2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators | GRUNENTHAL GMBH (DE) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152234-A1 | Substituted 4-(1,2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators | KCNAB1, KCNQ2, KCNQ1 | PRCP 4752/4885GAA 3833/4885KDM1A 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.