Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.55 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6115467 | 0.98 | LOXL2 (0.53) | LOXL2TLR8TLR7S1PR2LMNA | |
| SCHEMBL6114494 | 0.98 | LOXL2 (0.53) | LOXL2TLR8TLR7S1PR2LMNA | |
| SCHEMBL6114551 | 0.98 | LOXL2 (0.53) | LOXL2TLR8TLR7S1PR2LMNA | |
| SCHEMBL6114968 | 0.98 | LOXL2 (0.53) | LOXL2TLR8TLR7S1PR2LMNA | |
| SCHEMBL6114811 | 0.98 | LOXL2 (0.53) | LOXL2TLR8TLR7S1PR2LMNA | |
| SCHEMBL6115139 | 0.98 | LOXL2 (0.53) | LOXL2TLR8TLR7S1PR2LMNA | |
| SCHEMBL10585446 | 0.98 | LOXL2 (0.53) | LOXL2TLR8TLR7S1PR2LMNA | |
| SCHEMBL6115140 | 0.98 | LOXL2 (0.53) | LOXL2TLR8TLR7S1PR2LMNA | |
| SCHEMBL30665033 | 0.95 | LOXL2 (0.56) | LOXL2TLR8TLR7S1PR2LMNA | |
| SCHEMBL2237676 | 0.95 | LOXL2 (0.56) | LOXL2TLR8TLR7S1PR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527198-A | Method for preparing 4-arylquinoline from 2-aminodiaryl methanol | 长沙资材科技有限公司 | 2021-10-22 | — | — | CN | claimed |
| CN-112047882-A | New application of isoquinoline and quinoline derivatives in preparation of blood fat reducing drugs | 天津科技大学 | 2020-12-08 | — | — | CN | claimed |
| CN-118324694-A | Fluorescent compound for rapidly detecting explosive as well as preparation method and application thereof | 湖南华南光电科技股份有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-113527198-A | Method for preparing 4-arylquinoline from 2-aminodiaryl methanol | 长沙资材科技有限公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-113527198-A | Method for preparing 4-arylquinoline from 2-aminodiaryl methanol | 长沙资材科技有限公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-113527198-A | Method for preparing 4-arylquinoline from 2-aminodiaryl methanol | 长沙资材科技有限公司 | 2021-10-22 | — | — | CN | disclosed |
| US-10961266-B2 | Chemoselective methylene hydroxylation in aromatic molecules | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-03-30 | — | — | US | disclosed |
| US-10961266-B2 | Chemoselective methylene hydroxylation in aromatic molecules | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-03-30 | — | — | US | disclosed |
| CN-112047882-A | New application of isoquinoline and quinoline derivatives in preparation of blood fat reducing drugs | 天津科技大学 | 2020-12-08 | — | — | CN | disclosed |
| US-10654807-B2 | Toll-like receptor 8 agonists | THE UNIVERSITY OF KANSAS (US) | 2020-05-19 | — | — | US | disclosed |
| US-20200087331-A1 | CHEMOSELECTIVE METHYLENE HYDROXYLATION IN AROMATIC MOLECULES | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2020-03-19 | — | — | US | disclosed |
| WO-2005033103-A1 | QUINOLINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2005-04-14 | — | — | WO | disclosed |
| EP-0860433-B1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BREWERY (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-6388081-B1 | 4-substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries | LION BIOSCIENCE AG (DE) | 2002-05-14 | — | — | US | disclosed |
| US-6262269-B1 | 4-Substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries | TREGA BIOSCIENCES, INC. | 2001-07-17 | — | — | US | disclosed |
| US-6143764-A | ETHER DERIVATIVES OF QUINOLINE, ANTITUMOR AGENTS | KIRIN BEER KABUSHIKI KAISHA (JP) | 2000-11-07 | — | — | US | disclosed |
| EP-0977989-A1 | 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 2000-02-09 | — | — | EP | disclosed |
| EP-0860433-A1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 1998-08-26 | — | — | EP | disclosed |
| WO-1998034115-A1 | 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 1998-08-06 | — | — | WO | disclosed |
| WO-1997048705-A1 | POTASSIUM CHANNEL BLOCKERS | UNIVERSITY COLLEGE LONDON (GB) | 1997-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10654807-B2 | Toll-like receptor 8 agonists | TLR8, TLR7, TLR1 | LOXL2 622/4885TLR8 1/4885TLR7 2/4885 |
| US-10961266-B2 | Chemoselective methylene hydroxylation in aromatic molecules | PAH, DBH, AHR | LOXL2 3162/4885TLR8 4000/4885TLR7 3874/4885 |
| US-20200087331-A1 | CHEMOSELECTIVE METHYLENE HYDROXYLATION IN AROMATIC MOLECULES | PAH, DBH, AHR | LOXL2 3162/4885TLR8 4000/4885TLR7 3874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.