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Sugi Predict / Compounds / SCHEMBL23645238

SCHEMBL23645238

SCHEMBL23645238

CC(C)Nc1ccc([C@H]2C[C@@]3(C)C(CC[C@@]3(O)C#CC(C)(C)C)[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@@H]23)cc1F

nearest known ligand 0.69

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 P04150 19/20 0.69
▸ PGR P06401 9/20 0.69
▸ AR P10275 7/20 0.69
▸ CYP3A4 P08684 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20048216 1.00 NR3C1 (0.69) NR3C1PGRARCYP3A4
SCHEMBL23653763 0.90 NR3C1 (0.62) NR3C1PGRARCYP3A4
SCHEMBL23131209 0.89 NR3C1 (0.61) NR3C1PGRARCYP3A4
SCHEMBL20048203 0.88 NR3C1 (0.77) NR3C1PGRARCYP3A4
SCHEMBL22903935 0.88 NR3C1 (0.77) NR3C1PGRARCYP3A4
SCHEMBL22903833 0.88 NR3C1 (0.52) NR3C1PGRARCYP3A4
SCHEMBL20048340 0.86 NR3C1 (0.79) NR3C1PGRARCYP3A4
SCHEMBL20048249 0.85 NR3C1 (0.77) NR3C1PGRARCYP3A4
SCHEMBL19042724 0.83 NR3C1 (0.83) NR3C1PGRARCYP3A4
SCHEMBL22903964 0.82 NR3C1 (0.82) NR3C1PGRARCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3851444-A1 INHIBITORS OF GLUCOCORTICOID RECEPTOR Oric Pharmaceuticals, Inc. (US) 2021-07-21 — — EP disclosed
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