Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 16/20 | 0.82 |
| ▸ | PGR | P06401 | 12/20 | 0.82 |
| ▸ | AR | P10275 | 9/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | SHBG | P04278 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20048215 | 1.00 | NR3C1 (0.82) | NR3C1PGRARCYP3A4LMNA | |
| SCHEMBL19042724 | 0.92 | NR3C1 (0.83) | NR3C1PGRARCYP3A4LMNA | |
| SCHEMBL21729781 | 0.91 | NR3C1 (0.68) | NR3C1PGRARCYP3A4LMNA | |
| SCHEMBL19042673 | 0.90 | NR3C1 (1.00) | NR3C1PGRARCYP3A4 | |
| SCHEMBL23653772 | 0.89 | NR3C1 (0.88) | NR3C1PGRARCYP3A4 | |
| SCHEMBL20048092 | 0.89 | NR3C1 (0.88) | NR3C1PGRARCYP3A4 | |
| SCHEMBL22903935 | 0.88 | NR3C1 (0.77) | NR3C1PGRARCYP3A4 | |
| SCHEMBL21143409 | 0.88 | NR3C1 (0.76) | NR3C1PGRARCYP3A4LMNA | |
| SCHEMBL20048227 | 0.88 | NR3C1 (1.00) | NR3C1PGRARCYP3A4 | |
| SCHEMBL20048236 | 0.88 | NR3C1 (0.88) | NR3C1PGRARCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210017219-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210017219-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | NR3C1, NR3C2, MC2R | NR3C1 1/4885PGR 59/4885AR 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.